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Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_6 | Pages 8 - 8
1 May 2015
Angel C McNair R Fuller N Sexton S
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All patients with a MOM THR implanted at our unit were recalled for clinical examination, Oxford hip score, radiographs, MARS MRI and cobalt/chromium ion levels. Patients were sub-classified, determining further follow up: a regular screening programme or referral to a revision arthroplasty surgeon.

We identified 299 MOM THR's. 59 patients reported a recent deterioration in symptoms. 67 had an abnormal x-ray. 232 hips underwent MARS MRI: 66 showed mild MOM disease, 31 moderate MOM disease, 17 severe MOM disease. 117 had a substantial fluid collection around the hip. Serum cobalt/chromium ions were raised in 135 patients. 46 had one or both above 7 ppb. 148 THR's were referred to a revision surgeon. 21 have been revised and 14 are awaiting revision.

In total 64 hips have been revised. 13 were histologically proven ALVAL, 19 had clinical findings of ALVAL (not histologically confirmed), and 1 non-specific reaction to metal wear. 53 asymptomatic patients had evidence of soft tissue reaction on MRI and/or rising metal ions.

Our screening programme identified asymptomatic patients with evidence of a suspicious reaction to their MOM THR. We recommend all patients with a MOM THR are fully screened for ARMD regardless of symptoms and metal ion levels.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 5 - 5
1 Dec 2013
Angel C Sexton S MacNair R Fuller N
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Background:

Higher than expected revision rates have been observed in large bearing metal-on-metal total hip replacements. We have introduced a metal on metal hip screening clinic at our unit and report the results.

Methods:

All patients who had a metal-on-metal total hip replacement implanted at our unit were recalled to clinic. Screening consisted of clinical examination, Oxford hip score, radiographs, MARS MRI and serum cobalt/chromium ion levels. MRI scans were graded (Norwich Classification) by a single consultant radiologist who was blinded to the history, examination, and metal levels. Patients were sub-classified into 6 groups, which determined further follow up and were either entered into a regular screening programme or referred to a revision arthroplasty surgeon for a decision on whether revision was required


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_9 | Pages 28 - 28
1 Feb 2013
Macnair R Sexton S Pearce C
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Urinary catheterisation may be associated with a risk of infection in hip and knee arthroplasty, however post-operative urinary retention can be distressing for the patient. This study investigates the factors that might predict the need for post-operative catheterisation.

A prospective blinded study of 128 consecutive patients undergoing lower limb arthroplasty was carried out. Data obtained included sex, age, joint (hip or knee), prostate score (IPSS), previous urinary retention, co-morbidities and residual bladder volume after attempted complete voiding measured using an ultrasound bladder scanner. Anaesthetic type and requirement for urinary catheterisation postoperatively were recorded. Predictive risk factors were identified using binary logistic regression, and expressed as odds ratios (OR) and 95% confidence intervals (CI).

The mean age was 69.5 years. There were 56 males and 72 females. 38 patients (30%) required post-operative catheterisation. Logistic regression identified the following predictive risk factors: bladder scan volume per ml increase (OR 1.006; CI 1.000–1.012); male sex (OR 5.51; CI 2.01–15.16); previous catheter (OR 4.26; CI 1.53–11.82); spinal/epidural/combined spinal epidural anaesthesia (OR 6.78; CI 1.75–26.32); moderate IPSS score (OR 5.15; CI 1.73–15.37); severe IPSS score (OR 3.53; CI 0.605–20.54). Our model specificity is 91%, positive predictor value 71% and negative predictor value 82%.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 201 - 201
1 Jan 2013
Macnair R Pearce C Sexton S
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Introduction

Urinary catheterisation can cause bacteraemia and therefore may be associated with a risk of infection in hip and knee arthroplasty. However postoperative urinary retention can be distressing for the patient. This study investigates the factors that might predict the need for postoperative catheterisation in order to help develop a protocol to decide who should be electively catheterised.

Methods

A prospective blinded study of 128 consecutive patients undergoing lower limb arthroplasty was carried out. No patient underwent perioperative catheterisation. Data obtained included sex, age, joint (hip or knee replacement), prostate score (IPSS), previous urinary retention, comorbidities and residual bladder volume after attempted complete voiding measured using an ultrasound bladder scanner. The type of anaesthesia and the requirement for urinary catheterisation postoperatively were recorded. Predictive risk factors were identified using binary logistic regression, and expressed as odds ratios (OR) and 95% confidence intervals (CI).


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 127 - 127
1 May 2011
Yeung E Sexton S Walter W Walter W Zicat B
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Background: Squeaking in hip arthroplasty is a phenomenon that was described decades ago, but has only been brought back to attention recently. It occurs predominantly in ceramic on ceramic bearings, and has a reported incidence from less than 1% to 21%. The cause and the implication of squeaking are still unknown and many factors have been suggested to contribute. This study has looked into the patient factors to investigate if any clinical features are associated with an increased risk of squeaking.

Methods: All primary total hip arthroplasties with ceramic on ceramic bearing that were performed at our unit were reviewed and all squeaking hips presented are included in the study. Patient demographics and clinical outcome data were analysed and compared with matched controls from the silent hips.

Results: Between 1997 and 2008, 3375 primary hip arthroplasties in 3182 patients with ceramic on ceramic bearing were performed in our unit. Seventy one hips (2.1%) presented with squeaking on direct questioning and self reporting. Those patients were found to be taller, heavier and younger. They also have a significantly higher post-operative range of hip motion and higher Harris hip score when compared to matched controls. There was no difference in the satisfaction score. Only 4 patients (5.6%) presented with pain as well as squeaking, and 2 (2.8%) resulted in revision surgery for problematic squeaking.

Conclusions: We present the largest series of squeaking primary hip arthroplasties with ceramic on ceramic bearing to date. A number of patient factors were found to be associated with squeaking. The taller, heavier and younger patients with more flexible and functional hips were at a higher risk, presumably because these patients put greater mechanical demands on their hips. Majority of the patients with squeaking are pain free and there is only a small risk of requiring revision surgery.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 16 - 17
1 Jan 2011
Rajaratnam S Waters T Sexton S Walter W Zecat B Walter W
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Previously ankylosed or surgically arthrodesed hip joints can be converted successfully to a total hip replacement (THR) in order to improve patient mobility and function. We present a long term prospective cohort study of cementless revisions of previously ankylosed hips.

Sixteen hips (15 patients) with a mean age of 52 years (range 16 to 75) had ankylosed hips for a mean of 36 years (range 3.5 to 65 years). They all received a cementless THR between August 1988 and January 2003 and were prospectively followed-up for a mean of 11 years (range 5.0 to 19 years). Two patients died during the study period of unrelated causes and none were lost to follow-up.

All patients showed improved mobility and function following the conversion of their ankylosed hips. The Harris Hip Score improved from a pre-operative mean value of 70 (Standard Error of Mean (SEM) 3.4) to a post-operative value of 83 (SEM 4.4) at the latest review, which was statistically significant (p < 0.05).

There was one acetabular cup revision at 5 years post implantation for aseptic loosening. At a mean of 11 years post THR, all other femoral and acetabular components remained clinically and radiographically well fixed. One patient with systemic ankylosing spondylitis and spontaneous bilateral bony hip ankylosis developed the unusual complication of Paget’s disease of the left hemipelvis and proximal femur two years after successful bilateral THR surgery. His symptoms resolved following medical therapy for Paget’s disease.

We conclude that a previously ankylosed hip can be effectively converted to a cementless total hip replacement with good long term results.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 530 - 530
1 Oct 2010
Sexton S Jackson M Martell J Walter W Zicat B
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Introduction: Dislocation is the most common complication resulting in re-operation after total hip arthroplasty. This study investigates the association between acetabular prosthesis position, changes in femoral offset and leg length and the risk of dislocation.

Patients and Methods: All total hip arthroplasties performed over the past 17 years at one institution were reviewed. The posterolateral approach was used in all cases. Only hips that included all of the following were included in the study: diagnosis of primary osteoarthritis, no previous surgery, unconstrained liner. 3682 hips met the inclusion criteria. 60 hips (1.6%) sustained a dislocation. Cup inclination and version was determined from scanned radiographs using Hip Analysis Suite software (University of Chicago) in all hips that dislocated and a control group of 60 patients matched for femoral head size, sex, age at surgery, side of hip replacement, time from surgery, BMI, type of prosthesis and bearing surface. We compared femoral offset and length against the contralateral normal hip, on standardised radiographs. Therefore dislocation cases where the contralateral hip had been replaced, where arthritic changes were present, or where previous surgery had been undertaken were not included in the analysis. 24 dislocating hips were measured and compared with 48 controls matched using the same criteria as above. Radiographs were analysed using Hip Analysis Suite.

Results: There is a statistically significant difference (p=0.025) in anteversion between dislocators and matched controls. Inclination is not significantly associated with dislocation (p=0.536).

There is a relative risk of 3.0 of dislocation in cups with ≤15 degrees of anteversion compared with > 15 degrees of anteversion. This difference in dislocation is statistically significant (p< 0.01).

Increased femoral offset compared with the normal contralateral hip is statistically significantly associated with an increased risk of dislocation (p=0.03). Change in leg length is not associated with dislocation risk.

Discussion: Decreased cup anteversion is associated with an increased risk of dislocation in hips operated on via the postero-lateral approach. Our results indicate that the surgeon should aim for a minimum of 15 degrees of anteversion to reduce the risk of dislocation.

The increase in femoral offset in the prosthetic hip compared with the normal contralateral hip and its association with dislocation may be due to intraoperative attempts to compensate for an unstable hip by increasing offset. These results indicate that a surgeon should be cautious when increasing femoral offset alone to try and compensate for a potentially unstable hip. Other factors, for example acetabular version should be addressed, with readjustment of cup position intra-operatively if required.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 529 - 530
1 Oct 2010
Sexton S De Steiger R Jackson M Stanford T Walter W
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Introduction: Dislocation is the most common complication resulting in re-operation following total hip arthroplasty, accounting for 33.5% of revisions. This study investigates the relationship between bearing surface and the risk of revision due to dislocation.

Materials and Methods: Analysis was based on 110,239 primary total hip arthroplasties with a primary diagnosis of osteoarthritis. Data were collected by the Austra-lian Orthopaedic National Joint Replacement Registry from September 1999 to December 2007. The bearing surfaces were: 20627 (18.7%) ceramic-on-ceramic, 14001 (12.7%) ceramic-on-polyethylene, 12208 (11.1%) metal-on-metal, and 62437 (56.6%) metal-on-polyethylene. In 966 (0.8%) hips the bearing surface was unknown.

Results: There were 862 (0.8%) hips revised due to dislocation, with a rate of 0.3 revisions per 100 component years. Survival analysis with an end point of revision due to dislocation was performed. Revision for dislocation is potentially associated with variables other than bearing surface (including age and femoral component head size). Therefore analyses were stratified by femoral head size (≤28mm and > 28mm), and age (< 65 years and ≤65 years). There is a significantly higher rate of revision for dislocation in ceramic-on-ceramic bearing surfaces compared to metal-on-polyethylene bearing surfaces after adjustment for age, sex and head size in the head size < =28mm/Age < 65 group (hazard ratio = 1.53, 95% C.I. = 1.02 to 2.30, p=0.041) and the head size > 28mm/Age > =65 group (hazard ratio = 1.73, 95% C.I. = 1.10 to 2.74, p=0.016).

Discussion: Ceramic-on-ceramic bearing surfaces have a higher risk of revision due to dislocation in the femoral head sizes and ages discussed above, compared with metal-on-polyethylene. Possible mechanisms for this observed difference may include patient selection, the limits to head and liner offset options when using ceramic bearing surfaces or higher rates of revision after dislocation due to ceramic head or liner damage. However our results are based on a seven year follow-up, and higher rates of late dislocation with polyethylene bearings may be observed in association with higher wear rates compared with ceramic liners.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 142 - 142
1 Mar 2010
Sexton S Rajaratnam S Walter W Zicat B Walter W
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Previously ankylosed or surgically arthrodesed hip joints can be converted successfully to a Total Hip Replacement (THR) in order to improve patient mobility and function. We present a long term prospective cohort study of cementless revisions of previously ankylosed hips.

Sixteen hips (15 patients) with a mean age of 52 years (range 16 to 75) had ankylosed hips for a mean of 36 years (range 3.5 to 65 years). They all received a cement-less THR between August 1988 and January 2003 and were prospectively followed-up for a mean of 11 years (range 5.0 to 19 years). Two patients died during the study period of unrelated causes and none were lost to follow-up.

All patients showed improved mobility and function following the conversion of their ankylosed hips. The Harris Hip Score improved from a pre-operative mean value of 70 (Standard Error of Mean (SEM) 3.4) to a post-operative value of 83 (SEM 4.4) at the latest review, which was statistically significant (p < 0.05). There was one acetabular cup revision at 5 years post implantation for aseptic loosening. At a mean of 11 years post THR, all other femoral and acetabular components remained clinically and radiographically well fixed.

One patient with systemic ankylosing spondylitis and spontaneous bilateral bony hip ankylosis developed the unusual complication of Paget’s disease of the Left hemipelvis and proximal femur two years after successful bilateral THR surgery. His symptoms resolved following medical therapy for Paget’s disease.

We conclude that a previously ankylosed hip can be effectively converted to a cementless total hip replacement with good long term results.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 186 - 187
1 Mar 2010
Sexton S Rajaratnam S Walter W Zicat B Walter W
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Dislocation remains a common complication following total hip arthroplasty, second only to aseptic loosening as a cause of revision. Factors thought to play a role in dislocation include cup and stem alignment, soft tissue tension, surgical approach, patient factors, and design features of the prosthesis, including femoral head size.

We analysed all consecutive total hip replacements at one institution over a 17 year period. Criteria for study inclusion were hips replaced due to primary osteoarthritis with no previous surgery, femoral head sizes of 28mm and 32mm only, and at least one year from date of surgery. 3682 hips fulfilled these criteria. All procedures were carried out using a posterolateral approach with enhanced posterior repair, and a standard method of intraoperative soft tissue balance assessment.

The rate of dislocation was 1.6%. 32mm femoral head size was associated with a statistically significant lower rate of dislocation. However, after controlling for different follow-up times between 28mm and 32mm heads, this difference was no longer observed. Older age at time of surgery and decreased cup anteversion were shown to be significantly associated with an increased risk of dislocation. Ceramic on ceramic bearing surface was significantly associated with a decreased risk of dislocation, after controlling for age, bearing wear and time from surgery. Cup inclination, gender, BMI, and preoperative hip score were not related to dislocation risk.

Our dislocation rate may reflect current dislocation rates of surgeons using the posterolateral approach with posterior capsule and external rotator repair. The risk factors identified and excluded in this study are likely to be relevant to all surgeons who utilise this approach in total hip arthroplasty.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 107 - 107
1 Mar 2010
Sexton S Rajaratnam S Walter W Zicat B Walter W
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Dislocation remains a common complication following total hip arthroplasty, second only to aseptic loosening as a cause of revision. Factors thought to play a role in dislocation include cup and stem alignment, soft tissue tension, surgical approach, patient factors, and design features of the prosthesis, including femoral head size.

We analysed all consecutive total hip replacements at one institution over a 17 year period. Criteria for study inclusion were hips replaced due to primary osteoarthritis with no previous surgery, femoral head sizes of 28mm and 32mm only, and at least one year from date of surgery. 3682 hips fulfilled these criteria. All procedures were carried out using a posterolateral approach with enhanced posterior repair, and a standard method of intraoperative soft tissue balance assessment.

The rate of dislocation was 1.6%. 32mm femoral head size was associated with a statistically significant lower rate of dislocation. However, after controlling for different follow-up times between 28mm and 32mm heads, this difference was no longer observed. Older age at time of surgery and decreased cup anteversion were shown to be significantly associated with an increased risk of dislocation. Ceramic on ceramic bearing surface was significantly associated with a decreased risk of dislocation, after controlling for age, bearing wear and time from surgery. Cup inclination, gender, BMI, and preoperative hip score were not related to dislocation risk.

Our dislocation rate may reflect current dislocation rates of surgeons using the posterolateral approach with posterior capsule and external rotator repair. The risk factors identified and excluded in this study are likely to be relevant to all surgeons who utilise this approach in total hip arthroplasty.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 125 - 125
1 Mar 2009
Sexton S Kamat Y Pearce C Adhikari A
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Introduction: Computer assisted knee arthroplasty (CAKA) has been shown in a number of studies to result in improved post-operative alignment of prostheses. However prosthetic alignment is only one part of total knee arthroplasty surgery and outcome is likely to depend on other factors such as soft tissue balancing.

Our study compared the functional outcome following knee arthroplasty using CAKA or conventional instrumentation, and investigated whether the theoretical advantage of improved prosthesis alignment with CAKA resulted in improved functional outcome.

Materials and Methods: Data on 299 patients have been recorded to date. 139 patients have a minimum one year follow up. No patients were lost to follow up. All patients were operated on by a single surgeon at a dedicated arthroplasty centre and were allocated to one of two groups: Computer assisted navigation using a robot assisted technique (PiGalilieo, Plus Orthopaedics, Rotkreuz, Switzerland), or using conventional instrumentation. In both groups the prosthesis used was the TC-Plus Self-aligning bearing (Plus Orthopaedics).

Functional outcome was measured using the Oxford Knee Score (OKS).

A power analysis was performed with alpha of 0.05 and power of 80%. In order to detect a difference of 4 points in the OKS, 126 patients were required. This number was exceeded in our study at one year.

Results: The mean OKS at one year follow up was 24.9 (range 12 – 54, s.d. 9.8) for the CAKA group and 25.3 (range 12–49, s.d. 9.7) for the control group. There was no significant difference in functional outcome at one year between the two groups (p = 0.41).

At two years follow up the mean OKS was 25.39 (range 13 – 53, s.d. 10.3) for the CAKA group and 24.14 (range 12–43, s.d. 9.1) for the control group (p = 0.33). The results for the two year follow up group should be treated with caution as further patient numbers are awaited to obtain adequate power.

Conclusions: Although several studies show that use of CAKA results in improved prosthesis alignment, our study indicates that CAKA does not result in improved functional outcome as assessed by the patient at short term follow up. Improved prosthesis alignment is thought to result in improved long term outcome, however long term studies are necessary to show whether the known advantages of CAKA in improved prosthesis alignment results in improved patient satisfaction and increased implant survival. These further studies are important in order to justify the increased costs associated with CAKA.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 2 | Pages 186 - 188
1 Feb 2008
Pearce CJ Sexton S Gerrard D Hatrick A Solan M

Chronic infections and ulceration around the tendo Achillis are difficult to manage. Split-skin grafts do not survive even on healthy exposed tendon. Refractory cases may require plastic surgical intervention with the use of free flaps. Patients with significant vascular disease are not suitable for such techniques. Flexor hallucis longus tendon transfer is an established treatment for chronic ruptures of the tendo Achillis.

We report the successful treatment of an infected tendo Achillis with excision and reconstruction with flexor hallucis longus transfer. The muscle belly of this tendon allowed later skin grafting while the tendon transfer provided good functional recovery.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 228 - 228
1 Mar 2004
Haddad F Stossel C Sexton S
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Background: Revision total hip replacement is challenging when there is severe proximal bone loss. The Kent hip femoral prosthesis – a distally locked femoral stem – was designed to overcome this difficulty, however no study to date has assessed its durability. Methods: We independently reviewed the results of 105 Kent Hip Prostheses used at one hospital between 1987 and 2000. The indication for revision was aseptic loosening in 64, periprosthetic fracture in 19, septic loosening in 4, and severe bony deformity in 14. In the remaining 4 cases, a Kent hip prosthesis was inserted in the presence of metastatic tumour in the proximal femur to enable mobilisation. A functional evaluation of these patients using the Oxford Hip Score and a survival analysis of the stems was performed. Results: The mean duration of follow-up was 5.3 years (range 20 months to 15 years). The mean time to full weight bearing following surgery was 4 days and mean hospital stay was 13 days. Almost all patients experienced substantial improvement in hip related pain and disability (as measured by the Oxford Hip Score). 12 stems required further revision. Taking removal of the stem for any cause as the end point, cumulative survival at 15 years was 88%. Conclusions: Cumulative survival rates for the Kent hip femoral prosthesis compare favourably with other revision stems used where there is severe proximal bone loss. It enables early full weight bearing and hospital discharge, resulting in a low post-operative medical complication rate. However the need for continuing follow-up remains, since the rate of complications such as locking screw fracture, aseptic loosening, and periprosthetic fracture, may increase in the future.