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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 260 - 260
1 Jul 2014
Dudhia J Werling N Dakin S Goodship A Smith RW
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Summary

Treatment of equine naturally occurring over-strain tendinopathy with mesenchymal stem cells suspended in bone marrow supernatant resulted in significant improvements compared to saline treated tendons in the normalisation of biomechanical, morphological, and compositional parameters with no adverse effects.

Introduction

Tendon injuries are a common age-related degenerative condition where natural repair involves scarification, resulting in a functionally inferior tissue1 that frequently re-injures. Naturally-occurring human and equine tendinopathy possess many similarities2 making the horse a good clinically-relevant model. A multitude of treatments are used but few have a strong evidence base. Regenerative approaches using mesenchymal stem cells (MSCs) to improve outcome are supported by clinical data demonstrating reduced re-injury rates in racehorses3. We therefore hypothesised that implantation of autologous MSCs into injured equine tendons would result in a tissue more closely resembling normal tendon matrix than the fibrous scar tissue formed subsequent to natural repair. The aim of this controlled experimental study was to assess the biomechanical, histological and compositional parameters following MSCs implantation into naturally injured tendons.