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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 25 - 25
1 Jul 2014
Takeuchi H Enomoto H Matsunari H Umeyama K Nagashima H Yoshikawa T Okada Y Toyama Y Suda Y
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Summary

A novel in vivo animal model to establish new surgical interventions for patients with ACL insufficiency.

Introduction

After ACL reconstruction, recruited cells from surrounding tissues play crucial roles in ligamentization to obtain adequate structural properties. To allow athletes to return sports activity sooner, these remodeling processes should be elucidated and be accelerated. However, in conventional animal models, it has been difficult to differentiate donor and recipient cells. Here we introduce the transgenic Kusabira-Orange pigs, in which cells produce fluorescence systemically, as in vivo model to trace cell recruitment after ACL reconstruction.