Corticosteroids are prescribed for the treatment of many medical conditions and their adverse effects on bone, including steroid-associated osteoporosis and osteonecrosis, are well documented. Core decompression is performed to treat osteonecrosis, but the results are variable. As steroids may affect bone turnover, this study was designed to investigate bone healing within a bone tunnel after core decompression in an experimental model of steroid-associated osteonecrosis. A total of five 28-week-old New Zealand
Growth plates taken from five- to 20-week-old Japanese white
Osteomyelitis was induced in the tibiae of
Several bisphosphonates are now available for the treatment of osteoporosis. Porous hydroxyapatite/collagen (HA/Col) composite is an osteoconductive bone substitute which is resorbed by osteoclasts. The effects of the bisphosphonate alendronate on the formation of bone in porous HA/Col and its resorption by osteoclasts were evaluated using a rabbit model. Porous HA/Col cylinders measuring 6 mm in diameter and 8 mm in length, with a pore size of 100 ÎĽm to 500 ÎĽm and 95% porosity, were inserted into a defect produced in the lateral femoral condyles of 72
1. In young
We produced large full-thickness articular cartilage defects in 33
1. Articular cartilage from immature
The intermittent administration of cortisone in both the young and the mature
1. Small indian ink marks were made at intervals along the length of tendons in the limbs of young
1. The epiphyses of the metatarsal heads of 250-gramme
The effects of gamma irradiation on the growth plate have been studied in nineteen
1. The utilisation of labelled proline in normal and injured mature
In a rabbit model we investigated the efficacy of a silk fibroin/hydroxyapatite (SF/HA) composite on the repair of a segmental bone defect. Four types of porous SF/HA composites (SF/HA-1, SF/HA-2, SF/HA-3, SF/HA-4) with different material ratios, pore sizes, porosity and additives were implanted subcutaneously into Sprague-Dawley rats to observe biodegradation. SF/HA-3, which had characteristics more suitable for a bone substitite based on strength and resorption was selected as a scaffold and co-cultured with
1. As previous experiments with autogenous transplantation of epiphysial growth plates have given limited success, a study was carried out on two groups of
1. The changes resulting from superficial scarification of articular cartilage have been observed in the knee joint of adult
1. By the surgical division of the main capsular artery supplying the upper femoral epiphysis of the
We investigated the effects of low-intensity pulsed ultrasound on distraction osteogenesis in a rabbit model. Callotasis of the right tibia was performed in 70 male Japanese white
1. Because of the controversy over the clinical effects of corticosteroids on joint tissues a series of experiments on the knee joints of
The feasibility of bone transport with bone substitute and the factors which are essential for a successful bone transport are unknown. We studied six groups of 12 Japanese white
We investigated the effect of bone lengthening by callotasis on longitudinal growth of the tibia in