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The Journal of Bone & Joint Surgery British Volume
Vol. 74-B, Issue 4 | Pages 605 - 613
1 Jul 1992
Amis A Camburn M Kempson S Radford W Stead A

We excised the anterior cruciate ligament from the left stifle of 24 sheep and replaced it by a polyester fibre implant routed 'over the top' of the femoral condyle and fixed, using grommets and screws. All the joints were sound, and the animals moved normally until they were killed at six, 12 and 24 months after operation. We found that the implants were always covered by host tissue, which matured into bundles with a histological appearance similar to the natural ligament. The implants were joined to the bones by organised fibrous tissue and there was no anchorage loosening. There was no synovitis, but the operated joints showed progressive cartilage degeneration. The reconstructed joints became less stable immediately after operation, but regained normal stability as the neoligaments developed. The neoligaments lost strength with time, despite tissue ingrowth. The good functional, biomechanical, and histological results justify clinical trials of this type of implant.


The Journal of Bone & Joint Surgery British Volume
Vol. 70-B, Issue 4 | Pages 628 - 634
1 Aug 1988
Amis A Kempson S Campbell Miller J

The anterior cruciate ligament was replaced in rabbits, using implants of carbon or polyester filaments with known mechanical properties. The biocompatibility of the implants was assessed in detail using light microscopy, and scanning and transmission electron microscopy. Mechanical tests were made of stability, in comparison with normal joints and controls after excision of the ligament. Some carbon fibre implants broke down in vivo, allowing instability; the fragments caused chronic inflammation. Intact carbon implants did not induce the formation of neoligaments; they were covered by tissue, but there was no ingrowth. Polyester did not degrade mechanically and supported early collagenous ingrowth within the implant, even in the mid-joint space. It was concluded that there was no justification for the use of carbon fibres as anterior cruciate replacements; polyester appeared to be suitable.


The Journal of Bone & Joint Surgery British Volume
Vol. 66-B, Issue 1 | Pages 131 - 139
1 Jan 1984
Amis A Campbell Kempson S Miller J

Carbon-fibre and polyester-fibre implants of comparable dimensions were used to replace the calcaneal tendon in 30 sheep. The neotendon produced in proximity to the polyester fibres was denser, more collagenous and more closely adherent than that in the carbon-based neotendon. Fragmentation of the carbon caused continuing cellular reaction which was associated with a poor collagen response.