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Volume 11, Issue 1 January 2022

Reviewer Acknowledgement
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Nike Walter Markus Rupp Susanne Baertl Volker Alt
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Infographic
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Nike Walter Markus Rupp Susanne Baertl Tomasz Piotr Ziarko Florian Hitzenbichler Sebastian Geis Christoph Brochhausen Volker Alt
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Editorial
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Gordon T. Snowden Nick D. Clement Shenqi Zhang Qingyun Xue A. Hamish R. W. Simpson
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Fuquan Zhang Shuquan Rao Ancha Baranova
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Aims

Deciphering the genetic relationships between major depressive disorder (MDD) and osteoarthritis (OA) may facilitate an understanding of their biological mechanisms, as well as inform more effective treatment regimens. We aim to investigate the mechanisms underlying relationships between MDD and OA in the context of common genetic variations.

Methods

Linkage disequilibrium score regression was used to test the genetic correlation between MDD and OA. Polygenic analysis was performed to estimate shared genetic variations between the two diseases. Two-sample bidirectional Mendelian randomization analysis was used to investigate causal relationships between MDD and OA. Genomic loci shared between MDD and OA were identified using cross-trait meta-analysis. Fine-mapping of transcriptome-wide associations was used to prioritize putatively causal genes for the two diseases.


Hosam E. Matar Simon R. Platt Benjamin V. Bloch Tim N. Board Martyn L. Porter Hugh U. Cameron Peter J. James
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Maoxiao Ma Zhen Tan Wuyin Li Hong Zhang Youwen Liu Chen Yue
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Maoxiao Ma Zhen Tan Wuyin Li Hong Zhang Youwen Liu Chen Yue
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William H. Trousdale Afton K. Limberg Nicolas Reina Christopher G. Salib Roman Thaler Amel Dudakovic Daniel J. Berry Mark E. Morrey Joaquin Sanchez-Sotelo Andre van Wijnen Matthew P. Abdel
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Aims

Outcomes of current operative treatments for arthrofibrosis after total knee arthroplasty (TKA) are not consistently positive or predictable. Pharmacological in vivo studies have focused mostly on prevention of arthrofibrosis. This study used a rabbit model to evaluate intra-articular (IA) effects of celecoxib in treating contracted knees alone, or in combination with capsular release.

Methods

A total of 24 rabbits underwent contracture-forming surgery with knee immobilization followed by remobilization surgery at eight weeks. At remobilization, one cohort underwent capsular release (n = 12), while the other cohort did not (n = 12). Both groups were divided into two subcohorts (n = 6 each) – one receiving IA injections of celecoxib, and the other receiving injections of vehicle solution (injections every day for two weeks after remobilization). Passive extension angle (PEA) was assessed in live rabbits at 10, 16, and 24 weeks, and disarticulated limbs were analyzed for capsular stiffness at 24 weeks.


Wen-ting Liao Jia-dong Sun Yun Wang Yi-qing He Kai Su Yun-yang Lu Guiqing Liao Yang-peng Sun
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Aims

In the repair of condylar cartilage injury, synovium-derived mesenchymal stem cells (SMSCs) migrate to an injured site and differentiate into cartilage. This study aimed to confirm that histone deacetylase (HDAC) inhibitors, which alleviate arthritis, can improve chondrogenesis inhibited by IL-1β, and to explore its mechanism.

Methods

SMSCs were isolated from synovium specimens of patients undergoing temporomandibular joint (TMJ) surgery. Chondrogenic differentiation potential of SMSCs was evaluated in vitro in the control, IL-1β stimulation, and IL-1β stimulation with HDAC inhibitors groups. The effect of HDAC inhibitors on the synovium and condylar cartilage in a rat TMJ arthritis model was evaluated.