Advertisement for orthosearch.org.uk
You currently have no access to view or download this content. Please log in with your institutional or personal account if you should have access to through either of these
The Bone & Joint Journal Logo

Receive monthly Table of Contents alerts from The Bone & Joint Journal

Comprehensive article alerts can be set up and managed through your account settings

View my account settings

CROSS-SPECIES GRAFTS OF DEPROTEINISED BONE



Download PDF

Abstract

1. Cancellous bone cubes from calf and man were deproteinised with hydrogen peroxide and with ethylenediamine.

2. Long bones were removed aseptically from sheep, stored in the bone bank and used for cancellous homografts.

3. Holes were drilled in the upper part of the tibia or ulna or in the lower part of the femur of sheep. Some were left empty; others were filled with plugs of the deproteinised heterogenous bone, with autografts, or with homografts.

4. Histological appearances were studied after seventeen and thirty-six days.

5. At seventeen days repair was more advanced in the plugged holes; the biological result was better with the ethylenediamine-treated than with the peroxide-treated material. After thirty-six days repair was at an advanced stage. As much new bone had been deposited on the trabeculae of the deproteinised heterografts as on those of the homografts.

6. There was no evidence of metaplastic bone formation; new bone seemed to form from endosteal osteoblasts.

7. Certain clinical implications are briefly discussed.

For access options please click here