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Research

Dupuytren’s disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor



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Abstract

In a series of 12 patients with inoperable gastric carcinoma who had treatment with a synthetic matrix metalloproteinase inhibitor (Marimastat) for more than one month, six developed a frozen shoulder or a condition resembling Dupuytren’s disease.

This suggests that the matrix metalloproteinases, a family of naturally occurring proteinases, may be involved in the pathogenesis of these two conditions. Our observation opens avenues for further research which could lead to local or systemic therapeutic interventions for frozen shoulder and Dupuytren’s disease.


Correspondence should be sent to Mr J. W. Hutchinson at 23 Charnock Avenue, Wollaton Park, Nottingham NG8 1AG, UK.

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