Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint: STUDY IN A CANINE MODEL

D. Sabo; D. R. C. Brocai; M. Eble; M. Wannenmacher; V. Ewerbeck

doi:10.1302/0301-620X.82B2.0820276

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Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint

STUDY IN A CANINE MODEL

D. Sabo
D. R. C. Brocai
M. Eble
M. Wannenmacher
V. Ewerbeck

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Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint

Sabo D, Brocai DRC, Eble M, Wannenmacher M, Ewerbeck V. Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint. J Bone Joint Surg Br. 2000;82-B(2):276-282. doi:10.1302/0301-620X.82B2.0820276

Sabo, D., et al. “Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint.” The Journal of Bone & Joint Surgery British Volume, vol. 82-B, no. 2, 2000, pp. 276-282., https://doi.org/10.1302/0301-620X.82B2.0820276

Sabo, D., Brocai, D. R. C., Eble, M., Wannenmacher, M., & Ewerbeck, V. (2000). Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint. The Journal of Bone & Joint Surgery British Volume, 82-B(2), 276-282. https://doi.org/10.1302/0301-620X.82B2.0820276

Sabo, D., Brocai, D. R. C., Eble, M., Wannenmacher, M. and Ewerbeck, V. (2000) “Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint.” The Journal of Bone & Joint Surgery British Volume, 82-B(2), pp. 276-282. Available at: https://doi.org/10.1302/0301-620X.82B2.0820276

Sabo, D., D. R. C. Brocai, M. Eble, M. Wannenmacher, and V. Ewerbeck. “Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint.” The Journal of Bone & Joint Surgery British Volume 82-B, no. 2 (2000): 276-282. https://doi.org/10.1302/0301-620X.82B2.0820276

Sabo D, Brocai DRC, Eble M, Wannenmacher M, Ewerbeck V. Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint. J Bone Joint Surg Br. 2000 Mar 1;82-B(2):276-282. https://doi.org/10.1302/0301-620X.82B2.0820276

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Abstract

We studied the effects of irradiation on the reintegration of autologous osteoarticular grafts over a period of 24 weeks in a canine model. In 16 foxhounds the medial femoral condyle was resected, irradiated and immediately replanted. In the control group resection and replantation were performed without irradiation. Reintegration was assessed by macroscopic analysis, histology, radiography and gait analysis.

Reintegration was equal at 12 weeks, but significantly inferior in the irradiated group after 24 weeks with delayed bone remodelling. The articular cartilage showed modest degeneration. Conventional radiography and histology showed corresponding changes. Limb function was adequate but the gait was inferior in the treated group.

Correspondence should be sent to Dr D. Sabo.

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