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Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 339 - 339
1 Nov 2002
Burton AK McClune TDM Waddell. G
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Objective: A review of scientific literature on whiplash associated disorders was conducted to inform appropriate messages for an evidenced-based patient educational booklet – The Whiplash Book. The booklet has been developed for use as both a clinical tool and general health intervention. Design and Results: A systematic literature search was conducted, using MEDLINE and psychINFO, together with hand searches, reference tracking, and the Internet. The Quebec Task Force report and the British Columbia Whiplash Initiative were taken as the starting point. The new evidence covered the period May 1994 through March 2001 (163 articles). All relevant articles were included, with a particular focus on management and treatment of whiplash associated disorders. The quantity, consistency and relevance of all retrieved articles was evaluated, and rated as:. *** consistent findings in multiple reports. ** consensus based on balance of various findings. * limited information (single report). Conclusions: The main messages from the literature suggest: serious physical injury is rare, reassurance about good prognosis is important, over-medication is detrimental, fastest recovery occurs with early return to normal pre-accident activities; self-exercise/manual therapy and positive attitudes/beliefs are helpful to regain activity levels; collars/rest and negative attitudes/beliefs delay recovery and contribute to chronicity


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages - 92
1 Mar 2002
McClune T Burton A Waddell G
Full Access

A review of scientific literature on whiplash associated disorders was conducted to inform appropriate messages for an evidenced based patient educational booklet, “The Whiplash Book.” The booklet is being developed for use as both a clinical tool and general health intervention. A systematic literature search was conducted, using MEDLINE and psychINFO, together with hand searches, reference tracking, and the Internet. The Quebec Task Force report and the British Columbia Whiplash Initiative were taken as the starting point. The new evidence covered the period May 1994 through March 2001 (147 articles). All relevant articles were included, with a particular focus on management and treatment of whiplash associated disorders. The quantity, consistency and relevance of all retrieved articles was evaluated, and rated as *** for consistent findings in multiple reports, ** for consensus based on balance of various findings, or * for limited information (single report). The main messages from the literature suggest: physical serious injury is rare, reassurance about good prognosis is important, over-medication is detrimental, fastest recovery occurs with early return to normal pre-accident activities, self-exercise/manual therapy and positive attitudes/beliefs are helpful to regain activities levels, collars/rest and negative attitudes/beliefs delay recovery and contribute to chronicity


Prosthetic joint infection (PJI) is a serious complication following joint replacement. Antiseptic solutions are often used for intraoperative wound irrigation particularly in cases of revision for PJI. Antiseptic irrigation is intended to eradicate residual bacteria which may be either free floating or in residual biofilm although there is no clear clinical efficacy for its use. Also, reviewing the scientific literature there is discordance in in vitro results where some studies questions antiseptic efficacy whilst others suggest that even at low concentration antiseptic agents are effective at eradicating bacterial biofilms. The aim of this in vitro study was to establish the efficacy of undiluted antiseptic agents at eradication of a typical PJI forming biofilm and determine the importance of an antiseptic neutralisation step in this assessment. Mature Staphylococcus epidermidis biofilms grown on TiAl6V4 discs were submerged in chlorohexidine (CHL) gluconate 4%, povidone-iodine (PI) 10% or phosphate-buffered saline (PBS) control solution. The discs were then rinsed, the biofilm bacteria suspended in solution using sonication and vortexing, and the viable count (CFU/ml) of the bacterial suspensions determined. The rinse/suspension solution was either (a) PBS or (b) Dey-Engley neutralization broth (NB). When PBS was used to rinse/suspend the biofilm a highly significant, 7.5 and 4.1, mean log reduction in biofilm vitality was observed from the control, for CHL 4% and PI 10%, respectively. However, when NB was the rinse/suspension solution the apparent antiseptic biofilm eradication efficacy was replaced with a statistically significant but clinically irrelevant less the one log-reduction in biofilm vitality. Clinical antiseptic agents are ineffective at eradicating S. epidermidis biofilm in an in vitro PJI model and absence of a neutralisation step gives the false impression of efficacy. Antiseptics alone are an ineffective treatment for biofilm related PJI and no substitute for meticulous debridement


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_2 | Pages 31 - 31
10 Feb 2023
Minasian B Hope N
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Surfing has rapidly grown in popularity as the sport made its debut at the Tokyo 2020 Olympic Games. Surfing injuries are becoming more relevant with the globalisation and increasing risks of the sport, but despite this, little is known about surfing injuries or prevention strategies in either the competitive or recreational surfer. We reviewed the literature for the incidence, anatomical distribution, type and underlying mechanism of acute and overuse injuries, and discuss current preventative measures. Four online databases, including MEDLINE, PubMed, EMBASE and Cochrane Library were searched from inception to March 2020. This review finds that skin injuries represent the highest proportion of total injuries. Acute injuries most frequently affect the head, neck and face, followed by the lower limbs. Being struck by one's own board is the most common mechanism of injury. Surfers are injured at a frequency of 0.30–6.60 injuries per 1000 hours of surfing. Most prior studies are limited by small sample sizes, poor data collection methodology and geographical constraints. The scientific literature on surfing injuries under-represents overuse musculoskeletal injuries and the efficacy of prevention strategies for surfing-related overuse musculoskeletal injuries has not been studied. Injuries to the head and neck pose greater risks to a surfer's morbidity and mortality, yet there is no consensus on the management protocol of spinal injuries that occur in open water. Non-contact acute ligament injuries have increased as surfing manoeuvres have become more acrobatic, and overuse musculoskeletal injuries are highly correlated with paddling. Further research is needed to establish preventative measures for both acute and overuse surfing injuries and to ensure the increasing popularity of surfing is met with an improved understanding of sport risks and safety. Specifically, we recommend research be prioritised regarding the efficacy of training programmes to prevent surfing-related overuse musculoskeletal injuries


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_12 | Pages 99 - 99
1 Dec 2022
Morrison L Abbott A Mack Z Schneider P Hiemstra LA
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The number of women entering medical school has been steadily increasing over the past two decades; however, the number of women pursuing careers in orthopaedic surgery has not increased at the same rate. One of the suggested reasons for this discrepancy is the perceived incompatibility of having a family while upholding the demands of a surgical career in orthopaedics. A growing body of scientific literature has also outlined the increased rate of infertility and pregnancy complications in women surgeons. The extent to which these factors play a role in the recruitment and retention of women in orthopaedic surgery is unknown. Understanding pregnancy and parenthood in orthopaedic surgery is a critical first step in addressing this issue. A scoping review was conducted to identify literature pertaining to the perceptions and experiences of pregnancy and/or parenthood of women in orthopaedic surgery. Embase, MEDLINE and PsychINFO were searched on June 7th, 2021 with Boolean operators to combine the following terms: orthop?e*, pregnancy, maternity, motherhood, parenthood, parental, and parenting. Studies pertaining to orthopaedic surgery residents, fellows and staff were included. The Arksey and O'Malley framework for scoping studies was followed. Descriptive statistics were used to quantify the included studies while thematic analysis as described by Braun and Clarke was used to analyze the qualitative data. A total of 17 studies from 2006 to 2021 met inclusion criteria. Over half of the available research was conducted within the last two years (n=9, 53%). The majority of studies were conducted in the United States (n=15, 88%) and the United Kingdom (n=2, 12%). The most commonly used study design was survey-based research (n=13, 76%), followed by review studies (n=3, 18%), and case series (n=1, 6%). Thematic analysis revealed five key themes contributing to the women's experiences of pregnancy and/or parenthood in orthopaedics: (1) women are subtly or blatantly discouraged from becoming pregnant by their colleagues and superiors, (2) women delay childbearing to preserve their professional reputation, (3) there are higher rates of infertility and preterm labor in orthopaedic surgeons than in the general population, (4) the orthopaedic work environment can be hazardous and challenging for the pregnant woman, but accommodations are possible to mitigate risks, and (5) overall, there is limited support for pregnant and/or parenting women in orthopaedics throughout their career. The first woman to be board-certified in orthopaedic surgery in the United States was Ruth Jackson in 1937. Eighty-four years later, orthopaedic surgery has the lowest number of women of the surgical specialties. The barriers related to pregnancy and/or parenthood during a woman's career in orthopaedics may be one cause. This study identified five themes related to pregnancy and parenthood that warrant further investigation. Qualitative research approaches can be used to elucidate the details of women's experiences and to provide suggestions for structural changes in the orthopaedic work environment


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_5 | Pages 3 - 3
1 Mar 2021
Wittauer M Burch M Vandendriessche T Metsemakers W Morgenstern M
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Aim. Although non-unions being one of the most common complication after long-bone fracture fixation, the definition of this entity remains controversial and varies widely among authors. A clear definition is crucial, not only for the evaluation of published research data but also for the establishment of uniform treatment concepts. The aim of this systematic review was to identify the definitions and different criteria used in the scientific literature to describe non-unions after long bone fractures. Method. A comprehensive literature search was performed in PubMed, Cochrane Library, Web of Science, and Embase. according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Prospective therapeutic and diagnostic clinical studies in which adult long-bone fracture non-unions were investigated as main subject were included in this analysis. Results. One hundred fifty-two studies investigating 6432 long-bone non-unions met inclusion criteria for this analysis. In total 49% (75/152) of included studies did not define non-union at all, even though non-union was their main study subject. A definition of non-union on either clinical, radiologic or time criteria could be found in 51% (77/152) of the included studies. Non-union was defined based on time criteria in 83% (64/77), on radiographic criteria in 65% (50/77), and on clinical criteria in 43% (33/77). A combination of clinical, radiologic and time criteria for definition was only found in 35% (27/77) of all the included studies that defined non-union. The time point when authors defined an unhealed fracture as a nonunion showed a considerable heterogeneity, ranging from four to 24 months. Conclusions. In the current orthopaedic trauma literature, we found a lack of consensus with regard to the definition of long bones non-unions. Therefore, a standardized definition of non-union remains unclear. Without valid and reliable definition criteria of non-unions, the establishment of standardized diagnostic and treatment algorithms as well as the comparison of studies remain difficult. The lack of a clear definition emphasizes the need for consensus-based definition of fracture non-unions based on clinical, radiographic and time criteria


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_14 | Pages 87 - 87
1 Dec 2019
Burch MA Thompson K Eberli U Arens D Milstrey A Stadelmann V Richards G Moriarty F
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Aim. Non-steroidal anti-inflammatory drugs (NSAIDs) are a cornerstone of perioperative pain management in orthopedic trauma surgery, although concerns persist regarding the potential impact of these drugs on fracture healing. Furthermore, NSAIDs may also exert an influence on host immune defenses, which may also be important in the context of infection treatment. However, this has been very much under-investigated in the clinical and scientific literature. The aim of this study was to determine the impact of NSAIDs on the course of an orthopedic device-related infection (ODRI) and its response to antibiotic therapy in a rat model. Method. A polyetheretherketone (PEEK) screw was inserted in the proximal tibia of 48 skeletally mature female Wistar rats: 12 control animals received a sterile screw, of which 6 also received NSAID therapy (carprofen, 5 mg/kg s.c. once daily); 36 rats received a Staphylococcus epidermidis-inoculated screw, of which 18 received NSAID therapy. Antibiotic therapy was administered from day 7–21 in 9 animals from all groups receiving S. epidermidis-inoculated screws (cefazolin: 30 mg/kg; s.c., b.i.d. plus rifampin: 25 mg/kg; s.c., b.i.d.). Bone histomorphometric changes were monitored using longitudinal microCT scanning, performed postoperatively, and at 3, 6, 9, 14, 20 and 28 days (euthanasia). Quantitative bacteriology of the implant, bone and overlying soft tissue was performed to assess infection status of individual animals. Results. All animals receiving S. epidermidis-inoculated screws in the absence of antibiotic therapy were confirmed as infected at euthanasia. Quantitative microbiology showed no significant change in bacterial load in NSAID-treated animals versus control. However, NSAID administration dramatically impaired antibiotic efficacy, with 7/8 animals remaining infected when NSAIDs were co-administered, whilst only 2/9 of control animals were infected when NSAIDs were withheld. Pronounced osteolysis was observed by day 6–9 in control animals, with reparative processes (periosteal proliferation and mineralization) observed at day 14. NSAID treatment markedly prevented S. epidermidis-induced osteolysis, but also reparative processes. Antibiotic treatment did not affect the bone changes. Conclusions. NSAID administration dramatically affected the response of bone tissue to infection, reducing osteolysis but also impairing reparative processes. Crucially, NSAIDs dramatically reduced antibiotic efficacy. Given these pronounced negative effects, further investigations should be conducted to determine the underlying pathophysiological mechanism and better understand the consequences of the therapeutic use of NSAIDs in human patients with ODRI


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_9 | Pages 44 - 44
1 May 2017
De Faoite D
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Background. This survey was conducted to gain information about how surgeons use scientific literature and how this is influenced by their knowledge of evidence-based medicine. The results were compared to a survey conducted 10 years previously. Where appropriate, the same questions as in the 2003 survey were used. Methods. We administered a voluntary questionnaire to participants at the AO Foundation courses in Davos, Switzerland, in December 2013. We surveyed, amongst other topics, the surgeons’ levels of education in Evidence-Based Medicine (EBM), how they implement EBM in daily practice and their publication record. Results. A total of 330 surgeons completed the 27 question survey. 49% (159/322) had learned about EBM in medical school. However, 69% (110/159) of those with EBM education had taken only one semester or less on the subject. 54% of participants (170/317) correctly identified a definition of EBM in surgery. This compares to 45% in the 2003 survey (130/288 respondents) of a subset who said they have previously heard of evidence-based orthopaedic surgery. When it came to applying EBM in their daily work, 45% of respondents (143/320) claim to always practice it (2003 figure: 28%, 113/404), while 26% (84/320) only use EBM for difficult or controversial cases (2003 figure: 26%, 104/404). 27% (88/323) have never published a manuscript as an author or co-author (2003 figure: 14%, 121/453), 53% (170/323) have been involved in 1–10 publications (2003 figure: 59%, 269/453), and 20% (65/323) have published more than 10 times (2003 figure: 27%, 63/453). Conclusions. While at face value there appears to be a greater understanding and utilisation of EBM among AO course participants who completed the 2013 survey compared to the 2003 study, several outcomes do not show any great variation in the intervening decade. Level of Evidence. professional survey


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_13 | Pages 71 - 71
1 Nov 2015
Cuckler J
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My involvement in the DEFENSE side of MoM hip litigation has allowed me the luxury of reflection and continued study of the basic and clinical science and voluminous medical and scientific literature concerning this particular wear couple. Much of what I have learned is relevant to other articular couples, and might help you in your next THR. While useful, in vitro laboratory testing cannot wholly replicate or predict in vivo behavior of a particular wear couple. (Mother Nature always has something new to teach us!). Although MoM implants underwent rigorous pre-market testing and evaluation by the industry and appropriate regulatory approval in both the US and EU, the process cannot assure the clinical safety or success of new designs and materials for all implant recipients. Two year results obtained in pre-market (IDE) studies are of insufficient follow-up for accurate evaluation of the short, and certainly medium, or long-term clinical performance of new materials or designs, as demonstrated by the two year data from the Australian Joint Registry. In certain populations, MoM bearings have performed satisfactorily (to date) in individuals for whom traditional bearings were a poor option. Conclusions. Be conservative. Use appropriate clinical judgment and careful informed consent if you recommend new designs or materials to your patient


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_9 | Pages 14 - 14
1 Aug 2015
Jamjoom B Cooke S Ramachandran M Thomas S Butler D
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The aim was to assess contemporary management of slipped capital femoral epiphysis (SCFE) by surveying members of the British Society of Children's Orthopaedic Surgery (BSCOS). A questionnaire with 5 case vignettes was used. Two questions examined the timing of surgery for an acute unstable SCFE in a child presenting at 6 hours and at 48 hours after start of symptoms. Two further questions explored the preferred method of fixation in mild and severe stable SCFE. The final question examined the management of the contralateral normal hip. Responses were entered into an Excel spreadsheet and the data w analysed using a chi-squared test. The response rate was 56% (110/196). 88.2% (97/110) responded that if a child presented with an acute unstable SCFE within 6 hours, they would treat it within 24 hours of presentation, compared with 40.9% (45/110) for one presenting 48 hours after the onset of symptoms (P<0.0001). 52.6% (58/110) of surveyed BSCOS members would offer surgery for an unstable SCFE between 1 and 7 days after onset of symptoms. Single screw fixation in situ was advocated by 96.4% (106/110) and 70.9% (78/110) while corrective osteotomy was preferred by 1.8% (2/110) and 26.4% (29/110) of respondents for the mild and the severe stable slips respectively (P<0.0001). Surgeons preferring osteotomy are more likely to perform an intracapsular technique. Prophylactic fixation of the contralateral normal hip was performed by 27.3% (30/110) of participants. There are significant differences in opinions between BSCOS members as to the optimal management of SCFE in children. This reflects the variable recommendations and quality in the current scientific literature. Further research is therefore required to determine best practice and enable consensus to be reached


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_2 | Pages 108 - 108
1 Jan 2016
Kirking B
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The Stanford Upper Extremity Model (SUEM) (Holzbauer, Murray, Delp 2005, Ann Biomed Eng) includes the major muscles of the upper limb and has recently been described in scientific literature for various biomechanical purposes including modeling the muscle behavior after shoulder arthroplasty (Hoenecke, Flores-Hernandez, D'Lima 2014, J Shoulder Elbow Surg; Walker, Struk, Banks 2013, ISTA Proceedings). The initial publication of the SUEM compared the muscle moment arm predictions of the SUEM against various moment arm studies and all with the scapula fixed. A more recent study (Ackland, Pak, and Pandy 2008, J Anat) is now available that can be used to compare SUEM moment arm predictions to cadaver data for similar muscle sub-regions, during abduction and flexion motions, and with simulated scapular motion. SUEM muscle moment arm component vectors were calculated using the OpenSim Analyze Tool for an idealized abduction and an idealized flexion motion from 10° to 90° that corresponded to the motions described in Ackland for the cadaver arms. The normalized, averaged muscle moment arm data for the cadavers was manually digitized from the published figures and then resampled into uniform angles matching the SUEM data. Standard deviations of the muscle moment arms from the cadaver study were calculated from source data provided by the study authors. Python code was then used to calculate the differences, percent differences, and root-mean-square (RMS) values between the data sets. Of the 14 muscle groups in the SUEM, the smallest difference in predicted and measured moment arm was for the supraspinatus during the abduction task, with an RMS of the percent difference of 11.4%. In contrast, the middle latissimus dorsi had an RMS percent difference over 400% during the flexion task. The table presents the RMS difference and the RMS of the percent difference for the muscles with the largest abduction and adduction moment arms (during abduction) and the largest flexion and extension moment arms (during flexion). The moment arm data for the SUEM model and the cadaver data (with 1 standard deviation band) during the motion of the same muscles are provided in Figure 1 for the Abduction motion task and in Figure 2 for the Flexion motion task. It is challenging to simulate the three dimensional, time variant geometries of shoulder muscles while maintaining model fidelity and optimizing computational cost. Dividing muscles in to sub regions and using wrapping line segment approximations appears a reasonable strategy though more work could improve model accuracy especially during complex three dimensional motions


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_V | Pages 8 - 8
1 Mar 2012
Cowie J Thomson C McKinley J
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A Morton's neuroma is a painful forefoot disorder characterised by plantar pain and toe paraesthesia. Many treatments have been tried including modification of shoe wear, injections and surgery. The results from different treatment modalities are extremely variable in the scientific literature. We reviewed 79 patients who presented with an ultrasound proven Morton's Neuromata at an average of 60 months following treatment in a patient blind randomised trial. 35 had surgery with resection of the Morton's Neuromata. We compared the results of the patients who had had a steroid injection and surgery, a steroid injection alone, a placebo injection and then surgery and a placebo injection alone. We looked at the requirement for further consultations, pain scores, activity restrictions, footwear restriction, overall satisfaction with their treatment and overall quality of life scores. We found no significant difference between the groups. Overall 80% of the surgical patients had a good or excellent result and 67% of the non- operatively managed patients had a good or excellent result. There was no difference in their quality of life scores. Previous studies have shown little benefit in steroid injections in the treatment of Morton's Neuromata. We conclude at the five year mark there is no significant differences between operating on Morton's Neuromata and treating them conservatively. Further research should focus on comparing operative vs conservative treatment in the short to medium term. In order to justify the risks and costs of surgery


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_21 | Pages 28 - 28
1 Apr 2013
Cozon C Welck M Ray P
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Introduction. Venous thromboembolism (VTE) represents a major cause of morbidity, mortality and financial burden to the NHS. Acquired risk factors are well documented, including immobilisation, lower limb plaster cast and surgery. NICE guidance on VTE prophylaxis within orthopaedics currently excludes operative ankle fracture fixation (ankle ORIF). Aims. Ascertain the local incidence of VTE; compare our local VTE rates with published data from other institutions; review guidelines, scientific literature and other hospitals policies; formulate a local policy for VTE prophylaxis. Method. Retrospective analysis of records of all patients undergoing ankle ORIF in our hospital over a continuous 5 year period, identifying cases of VTE, individual risk factors and surgical duration. Results. 380 patients underwent ankle ORIF; 3 developed VTE; no mortality. VTE incidence 0.79% (0.26%DVT; 0.53%PE). Operative duration 88 +/− 34mins (mean +/− 1S.D); in those with VTE, duration was 35, 90&85min. There is no statistically significant difference (p=0.18) observed between our local and national VTE incidence rates. Operative duration was not a significant factor in those developing VTE. Additional risk factors were identified in one patient with VTE. Discussion. The incidence of heparin induced thrombocytopenia is 0.5%, its associated mortality 10% (i.e. 1:2000). To prevent one fatal PE in foot & ankle surgery, 10,000 must receive VTE prophylaxis. Therefore, heparin associated mortality exceeds VTE associated mortality in foot & ankle surgery. Conclusion. Our local VTE rates are comparable to national rates. Risk of pharmacological prophylaxis exceeds benefit; therefore routine use not justified. Individual risk should be assessed; higher risk patients may benefit


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 267 - 267
1 May 2009
Russo A Bragonzoni L Trozzi C Bruni D Marcacci M
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Aims: Neutral alignment and soft tissue balance are universally accepted as the most important objectives when performing a total knee replacement regardless of the preoperative deformity and implant type. Nevertheless, there is scarce evidence in the scientific literature of the effect of surgical correction on varus/valgus alignment variation during follow-up. We wanted to verify if the femur-tibial alignment after a total knee replacement was maintained at three years’ follow-up, and whether any variation might be correlated to anatomical characteristics before surgery, and to position and fixation of the tibial component within bone. Methods: We assessed thirty patients with a cemented TKR implant preoperatively, and at one and three years’ follow-up. Lower limb alignment and tibial component position were evaluated manually from antero-posterior radiographs in weight-bearing position. The tibial component varus/valgus migration was measured by Roentgen Stereophotogrammetry. Results: In spite of the correct alignment obtained during surgery, at 3 years’ follow-up 40% of patients presented an alignment variation of over 3°. The variation of deformity was not correlated with the preoperative deformity, nor with the tibial component position with respect to the tibial shaft nor with its migration. Conclusions: After total knee arthroplasty, the recurrence of deformity is a common finding in spite of correct alignment obtained during surgery, but it does not influence the clinical result at mid-term follow-up. Anyway the unbalanced forces determining variation in coronal alignment, at a longer follow-up might produce deficiency of soft tissue structures, loosening of the prosthesis component, or polyethylene failure, leading to revision surgery


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 258 - 258
1 Jul 2014
Dean B Lostin E Oakley T Morrey M Carr A
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Summary Statement. The effects of local glucocorticoid on tendon appear broadly negative and this supports the emerging clinical evidence which points toward significant long term harms associated with this treatment modality. Introduction. The use of locally administered glucocorticoid is widespread in the treatment of painful tendinopathy. Despite evidence of short term benefit, the emerging evidence points toward significant long term harms associated with this method of treatment, including an increased risk of recurrence, rupture and worsened clinical outcomes (1, 2). Our primary purpose was to summarise the known effects of locally administered glucocorticoid on tendon tissue and tendon cells. Methods. We conducted a systematic review of the scientific literature using the PRISMA and Cochrane guidelines of the Medline database using specific search criteria. Only studies analysing the effects of locally administered glucocorticoid on tendon tissue or tendon cells with adequate controls were included. Specific attention was paid to histological and biomechanical findings. Inclusion was agreed upon by two independent researchers after review of abstracts or full text. The search yielded 4424 results, of which 42 met the inclusion criteria. The final 42 articles consisted of 13 human in vitro studies, 15 animal in vivo studies and 14 animal in vitro studies. Results. Due to study heterogeneity, statistical pooling or meta-analysis of data was not possible. The results are therefore described qualitatively. Histologically, there was a loss of collagen structure (5 studies) and an increase in collagen necrosis (4 studies). The proliferation and viability of fibroblasts was reduced (11 studies). An increased inflammatory cell infiltrate was shown in 3 animal in vivo studies, while an increased fibroblast infiltrate was seen in 2 studies. Fibroblast migration was reduced in 2 in vitro studies. Collagen synthesis was reduced in 13 studies. An increased ratio of type 3 to type 1 Collagen was shown in 2 studies. Apoptosis was unaffected in 2 studies. 19 studies investigated the mechanical properties of tendon. Of these 7 showed deterioration in mechanical properties, 4 showed an improvement and 8 showed no difference. Discussion/Conclusion. Overall it is clear that the local administration of glucocorticoid has significant negative effects on tendon cells in vitro, such as reduced cell viability, cell proliferation and collagen synthesis. There is increased collagen disorganisation and necrosis as shown by animal in vivo studies. The mechanical effects are equivocal. This review supports emerging clinical evidence showing significant long term harms associated with glucocorticoid injections. There is clearly a significant need for better designed human trials with appropriate blinding and control arms to investigate the effects of glucocorticoid on both clinical outcomes and characteristics of tendon tissue


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_22 | Pages 3 - 3
1 May 2013
Berend K
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Resurfacing arthroplasty of the hip enjoyed a resurgence of enthusiasm. A recent article has documented that the media played a significant role in its popularity, making claims that were not substantiated in scientific literature. Proponents of resurfacing arthroplasty state that it is bone conserving, provides greater stability, enhances range of motion, leads to a more normal gait, facilitates increased activity levels, decreases risk of dislocation, decreases the risk of leg length discrepancy and find that it is easier to insert in the face of deformity or retained hardware. The naysayers state that it is a more difficult operative procedure associated with a higher learning curve. They note that there are few patients who meet the selection criteria and there is an increased risk of fracture of the femoral neck. Finally, there is concern over metal ion toxicity and adverse tissue reaction. Furthermore, as we explore the literature, several studies have observed that resurfacing requires a bigger cup and results in a significantly higher volume of normal bone reamed from the acetabulum. Other studies note decreased range of motion with resurfacing compared with total hip arthroplasty (THA) secondary to an unfavourable head to neck ratio resulting in increased impingement. While resurfacing is purported to enhance functional outcomes, one randomized trial of 48 patients, 24 each resurfacing and large head THA, compared with 14 healthy control subjects found no difference in gait speed and postural balance evaluations, functional test, and clinical data at 3, 6 and 12 months post-operative. In another study comparing 337 resurfacings with 266 ceramic-on-ceramic THA, at 24 months there was no difference in Harris hip score, pain score or function score, but a statistically greater improved Harris hip range of motion score in THA. In a large meta-analysis study comparing 3269 hip resurfacings (3002 patients) with average follow-up of 3.9 years to 5907 cementless THA (5907 patients) with average follow-up of 8.4 years, the observed rate of femoral revision due to mechanical failure was 2.6% for resurfacing versus 1.3% for THA, yielding annualized rates of 0.67% and 0.15% respectively. An analysis of hip resurfacing data from national joint registries found that hip resurfacing demonstrates an overall increased failure rate compared with THA, except in males younger than 65 years old having a diagnosis of primary osteoarthritis and except with head diameters larger than 50 mm, which may be especially relevant as a contraindication for use of the procedure in female patients


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 484 - 484
1 Aug 2008
Ashford C Tutuk B Kerr J McGregor A
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The FASTER study (Function after spinal treatment, exercise and rehabilitation) aims to evaluate, via a factorial RCT, the benefits of a rehabilitation programme and an education booklet for the postoperative management of patients undergoing discectomy or lateral nerve root decompression, each compared with “usual care”. Since the scientific literature reveals little evidence in favour of any specific exercises or approach, the rehabilitation programme had a general focus on simply getting people exercising and was based on Klaber-Moffett & Frost’s [2000] “Back to fitness” programme; classes include elements of stretching, strengthening, relaxation and an opportunity for discussion. Currently, 128 patients have been recruited into the study of which 65 have been randomised to receive rehabilitation, which is offered 6 weeks after their surgery. At the end of the 6 week period of rehabilitation classes, participants are requested to complete a questionnaire containing forced and open questions on the content, style, length, timeliness and usefulness of these classes. Feedback is very positive. In terms of class length 95% felt it was about right and easy to follow. All knew why they were doing the exercises, and 90% felt they had enough support and assistance during the classes. 95% would recommend to others. Important elements were noted to be; being with other people with the same problem, learning to exercise, gaining confidence and support and information from the staff. The average overall rating of the classes was 8.5/10. The results show that content of the rehabilitation classes appears to be pitched at the right level for post-operative patients and that the attendees are benefiting from interactions with each other and learning to exercise and be active. The impact of these classes on outcome remains to be determined


The Bone & Joint Journal
Vol. 105-B, Issue 7 | Pages 815 - 820
1 Jul 2023
Mitchell PD Abraham A Carpenter C Henman PD Mavrotas J McCaul J Sanghrajka A Theologis T

Aims

The aim of this study was to determine the consensus best practice approach for the investigation and management of children (aged 0 to 15 years) in the UK with musculoskeletal infection (including septic arthritis, osteomyelitis, pyomyositis, tenosynovitis, fasciitis, and discitis). This consensus can then be used to ensure consistent, safe care for children in UK hospitals and those elsewhere with similar healthcare systems.

Methods

A Delphi approach was used to determine consensus in three core aspects of care: 1) assessment, investigation, and diagnosis; 2) treatment; and 3) service, pathways, and networks. A steering group of paediatric orthopaedic surgeons created statements which were then evaluated through a two-round Delphi survey sent to all members of the British Society for Children’s Orthopaedic Surgery (BSCOS). Statements were only included (‘consensus in’) in the final agreed consensus if at least 75% of respondents scored the statement as critical for inclusion. Statements were discarded (‘consensus out’) if at least 75% of respondents scored them as not important for inclusion. Reporting these results followed the Appraisal Guidelines for Research and Evaluation.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 450 - 450
1 Sep 2009
Valera F Minaya F Melián A Veiga X Medina F Ortega C
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Ultrasound has been shown to have positive biological effects, including increased angiogenic, chondrogenic, and osteogenic activities. The aim of our study was to evaluate the evidence available in the scientific literature for the ultrasound treatment for tendon healing. To identify “best evidence” published research a computerized literature search of Medline, Cochrane, PEDro, IME, IBECS and ENFISPO. Keywords used to identify the study population and interventions were: ultrasound, low intensity pulsed ultrasound, physiotherapy, clinical trial, meta-analysis, practice guideline, randomized controlled trial, repair tendon and tendon healing. The scientific evidence of the group of selected documents were measured using the scale described by the US Preventive Task Force. The assignment of the evidence level to each study was evaluated independently by two reviewers without communication among them. To determine inter-rather reliability Kappa index it was used (K) with a value of CI of 95%. The study populations were 39 pertinent recovered documents. The findings suggest that therapeutic ultrasound can increase in collagen synthesis and enhance the maturation of collagen fibrils of repairing tendons. Researchers have reported that therapeutic ultrasound could facilitate tissue recovery and US with dosages between 0.125–3 W/cm2 have been used in the treatment of tendon ruptures reported an improvement in both strength and energy absorption capacity of repairing rabbit or rat tendons with 1-MHz continuous US. Best results were: continuous US at 1 MHz, 0.5w/cm2 starting from day 5 after injury, 20 treatment sessions, 4 mi each session. There is not a general consensus on the choice of parameters for US treatment and the evidence for efficacy of therapeutic. Limits of studies: The time needed to develop such an interface in humans was reported to be much longer than that reported in animal models. Continuous and low-intensity pulsed ultrasound was able to accelerate tendon healing and facilitating earlier physiotherapy


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 398 - 398
1 Sep 2005
Ryan MD
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Introduction A frequently asked medico-legal question is whether or not an accident or injury is responsible for the onset of nerve root pain. There is virtually no information available in the scientific literature, which answers this question. Methods. A search of the medical literature over the last 10 years was carried out. “Causes of disc protrusion” Medline. I designed and carried out a questionnaire of Members of the Spine Society of Australia, The Australian and New Zealand Orthopaedic Associations, and The Neurosurgical Society of Australasia. Each was questioned about symptoms, their quality, continuity, and time to onset after an accident. Reasons, which might lead the practitioner to conclude that there was no association, were documented, as well as the percentage of discogenic nerve root pain not caused by accident or injury,. Results 48% stated that there must be a continuity of symptoms from the time of the accident to the onset of root pain. 35% accepted that a maximum gap of 48 hours could be accepted before the onset of nerve root symptoms for a causal association to exist. The remainder said that up to 3 months of continuous ipsilateral somatic limb symptoms would be sufficient for an association between the accident and injury. Responders varied widely in their answer to the question “what % of acute discogenic nerve root pain is not caused by an accident or injury?” Responses ranged from 10 to 90%. Mean 58 %. Discussion There is a modest consensus about the circumstantial association of an accident or injury and the onset of nerve root pain. There is wide disparity about the causation of acute discogenic nerve root pain, in general